| Trade date | Director | Volume / Price | Trade value | Trade type |
|---|---|---|---|---|
| 13/10/2023 | Andrew Franklin | 42,053 @ 39.02p | £16,409.08 | Sell |
| 13/10/2023 | Andrew Franklin | 55,592 @ 1.00p | £555.92 | Exercise of Option |
| 13/10/2023 | Peter Butterfield | 74,343 @ 39.02p | £29,008.64 | Sell |
| 13/10/2023 | Peter Butterfield | 98,342 @ 1.00p | £983.42 | Exercise of Option |
| 20/07/2023 | Jo Le Couilliard | 40,957 @ 48.80p | £19,987.02 | Buy |
| 18/07/2023 | Richard Jones | 53,000 @ 47.10p | £24,963.00 | Buy |
| 18/07/2023 | Richard Jones | 53,000 @ 47.10p | £24,963.00 | Buy |
| 18/07/2023 | Andrew Franklin | 50,988 @ 49.00p | £24,984.12 | Buy |
| 19/11/2021 | Peter Butterfield | 269,417 @ 102.50p | £276,152.43 | Sell |
| 19/11/2021 | Peter Butterfield | 500,000 @ 47.50p | £237,500.00 | Exercise of Option |
| 21/04/2021 | Peter Butterfield | 93,000 @ 95.40p | £88,722.00 | Sell |
| 21/04/2021 | Peter Butterfield | 205,000 @ 53.00p | £108,650.00 | Exercise of Option |
| 23/06/2020 | David Cook | 63,879 @ 77.70p | £49,633.98 | Buy |
| 23/06/2020 | David Cook | 63,879 @ 77.70p | £49,633.98 | Buy |
| 07/05/2020 | Peter Butterfield | 161,915 @ 7,470.00p | £12,095,050.50 | Sell |
| 07/05/2020 | Peter Butterfield | 200,000 @ 4,750.00p | £9,500,000.00 | Exercise of Option |
| 05/12/2019 | Andrew Franklin | 1,371,616 @ 76.90p | £1,054,772.70 | Sell |
| 02/12/2019 | Andrew Franklin | 1,500,000 @ 46.75p | £701,250.00 | Exercise of Option |
| 07/10/2019 | Peter Butterfield | 2,791,546 @ 73.50p | £2,051,786.31 | Sell |
| 07/10/2019 | Peter Butterfield | 3,137,546 @ 34.50p | £1,082,453.37 | Exercise of Option |
| 22/01/2019 | Richard Jones | 15,000 @ 65.28p | £9,792.00 | Buy |
| 09/11/2018 | John Dawson | 1,100,000 @ 70.10p | £771,100.00 | Sell |
| 14/02/2017 | Peter Butterfield | 61,846 @ 48.75p | £30,149.93 | Sell |
| 14/02/2017 | Peter Butterfield | 90,222 @ 33.25p | £29,998.82 | Exercise of Option |
| 27/10/2016 | Peter Butterfield | 200,000 @ 47.50p | £95,000.00 | Exercise of Option |
| 27/10/2016 | Andrew Franklin | 400,000 @ 47.50p | £190,000.00 | Exercise of Option |
| 27/10/2016 | Andrew Franklin | 155,000 @ 47.50p | £73,625.00 | Exercise of Option |
| 22/09/2016 | John Dawson | 3,000,000 @ 45.25p | £1,357,500.00 | Sell |
| 03/05/2016 | David Cook | 47,879 @ 46.52p | £22,273.31 | Buy |
| 03/05/2016 | David Cook | 54,492 @ 46.54p | £25,360.58 | Buy |
| 22/12/2015 | Nigel Clifford | 66,740 @ 44.95p | £29,999.63 | Buy |
| 17/12/2015 | Andrew L Smith | 75,000 @ 41.00p | £30,750.00 | Buy |
| 23/06/2015 | Tony Booley | 1,155,000 @ 37.00p | £427,350.00 | Sell |
| 23/06/2015 | Tony Booley | 1,000,000 @ 37.00p | £370,000.00 | Sell |
| 16/06/2015 | Nigel Clifford | 58,227 @ 39.50p | £22,999.67 | Buy |
| 16/06/2015 | Nigel Clifford | 55,696 @ 39.50p | £21,999.92 | Buy |
| 17/01/2014 | Tony Booley | 300,000 @ 33.50p | £100,500.00 | Sell |
| 02/12/2013 | Tony Booley | 0 @ 0.00 | 0.00 | Notification of Holding |
| 02/12/2013 | John Dawson | 0 @ 0.00 | 0.00 | Notification of Holding |
| 21/06/2013 | John Dawson | 460,000 @ 35.00p | £161,000.00 | Sell |
| 11/06/2013 | Richard Wright | 762,376 @ 36.50p | £278,267.24 | Sell |
| 11/06/2013 | Richard Wright | 113,000 @ 7.75p | £8,757.50 | Exercise of Option |
| 11/06/2013 | Richard Wright | 649,376 @ 8.50p | £55,196.96 | Exercise of Option |
| 08/03/2013 | John Dawson | 0 @ 0.00 | 0.00 | Notification of Holding |
| 25/10/2012 | Tony Booley | 800,000 @ 30.50p | £244,000.00 | Sell |
| 13/06/2012 | Tony Booley | 1,400,000 @ 27.00p | £378,000.00 | Sell |
| 16/09/2011 | Richard Wright | 600,000 @ 30.50p | £183,000.00 | Sell |
| 16/09/2011 | Richard Wright | 463,624 @ 8.50p | £39,408.04 | Exercise of Option |
| 16/09/2011 | Richard Wright | 136,376 @ 8.25p | £11,251.02 | Exercise of Option |
| 31/12/2010 | Michael R B Gatenby | 0 @ 0.00 | 0.00 | Notification of Holding |
| 31/12/2010 | Thomas Theodore Casdagli | 0 @ 0.00 | 0.00 | Notification of Holding |
| 31/10/2010 | Peter Butterfield | 0 @ 0.00 | 0.00 | Notification of Holding |
| 06/05/2011 | Tony Booley | 1,110,000 @ 33.00p | £366,300.00 | Sell |
| 06/05/2011 | John Dawson | 2,250,000 @ 33.00p | £742,500.00 | Sell |
| 06/05/2011 | Tony Booley | 1,110,000 @ 8.50p | £94,350.00 | Exercise of Option |
| 28/04/2011 | Richard Wright | 130,000 @ 34.12p | £44,356.00 | Exercise of Option |
| 28/04/2011 | Tony Booley | 130,000 @ 34.12p | £44,356.00 | Exercise of Option |
| 19/04/2011 | Richard Wright | 0 @ 0.00 | 0.00 | Notification of Holding |
| 11/10/2010 | John Dawson | 0 @ 0.00 | 0.00 | Notification of Holding |
| 20/09/2010 | Tony Booley | 0 @ 0.00 | 0.00 | Notification of Holding |
| 13/09/2010 | Richard Wright | 363,624 @ 37.25p | £135,449.94 | Sell |
| 10/09/2010 | Richard Wright | 363,624 @ 8.25p | £29,998.98 | Exercise of Option |
| 08/09/2010 | John Dawson | 10,000,000 @ 0.00 | 0.00 | Transfer To |
| 07/07/2010 | Tony Booley | 25,584 @ 32.75p | £8,378.76 | Sell |
| 06/07/2010 | Tony Booley | 25,584 @ 9.25p | £2,366.52 | Exercise of Option |
| 06/07/2010 | Tony Booley | 79,416 @ 32.75p | £26,008.74 | Sell |
| 06/07/2010 | Tony Booley | 79,416 @ 9.25p | £7,345.98 | Exercise of Option |
| 21/06/2010 | Tony Booley | 0 @ 0.00 | 0.00 | Notification of Holding |
| 30/03/2010 | Tony Booley | 0 @ 0.00 | 0.00 | Notification of Holding |
| 26/03/2010 | Tony Booley | 489,250 @ 33.25p | £162,675.63 | Sell |
| 26/03/2010 | Tony Booley | 489,250 @ 16.50p | £80,726.25 | Exercise of Option |
| 25/03/2010 | John Dawson | 0 @ 0.00 | 0.00 | Notification of Holding |
| 08/02/2010 | Thomas Theodore Casdagli | 0 @ 0.00 | 0.00 | Notification of Holding |
| 08/02/2010 | Paul Ranson | 0 @ 0.00 | 0.00 | Notification of Holding |
| 08/02/2010 | Richard Wright | 0 @ 0.00 | 0.00 | Notification of Holding |
| 08/02/2010 | Andrew L Smith | 0 @ 0.00 | 0.00 | Notification of Holding |
| 08/02/2010 | Tony Booley | 0 @ 0.00 | 0.00 | Notification of Holding |
| 08/02/2010 | John Dawson | 0 @ 0.00 | 0.00 | Notification of Holding |
| 02/12/2009 | John Dawson | 0 @ 0.00 | 0.00 | Notification of Holding |
| 09/01/2009 | Tony Booley | 100,000 @ 4.00p | £4,000.00 | Buy |
| 27/10/2008 | Michael R B Gatenby | 220,000 @ 4.00p | £8,800.00 | Buy |
| 14/10/2008 | Andrew L Smith | 40,000 @ 4.00p | £1,600.00 | Buy |
| 15/10/2008 | Richard Wright | 100,000 @ 4.00p | £4,000.00 | Buy |
| 03/10/2007 | Andrew L Smith | 100,000 @ 8.85p | £8,850.00 | Buy |
| 12/09/2007 | Richard Wright | 90,768 @ 7.77p | £7,052.67 | Buy |
| 18/09/2006 | Andrew L Smith | 60,000 @ 16.00p | £9,600.00 | Buy |
| 22/02/2005 | Paul Ranson | 48,000 @ 15.50p | £7,440.00 | Buy |
| Name | Holding | Percent |
|---|---|---|
| Peter Butterfield | 696,686 | 0.00% |
| Andrew Franklin | 248,503 | 0.00% |
| Richard Jones | 68,000 | 0.00% |
| Jo Le Couilliard | 40,957 | 0.00% |
| Institution name | Holding | Percent |
|---|---|---|
| DBAY Advisors Limited | 151,076,240 | 27.96% |
| Slater Investments Ltd | 70,675,966 | 13.08% |
| Kempen Capital Management N.V. | 55,157,348 | 10.19% |
| MVM Life Science Partners | 40,561,900 | 7.90% |
| Blackrock, Inc. | 32,282,356 | 5.98% |
| Lombard Odier Asset Management (Europe) Limited | 27,264,340 | 5.04% |
| Rathbone Investment Mgt | 25,968,567 | 4.81% |
| GVQ Investment Management Ltd | 23,691,460 | 4.98% |
| FMR LLC | 23,287,384 | 4.31% |
| Polar Capital | 23,252,692 | 4.36% |
| Royal Bank of Canada | 20,645,236 | 0.00% |
| Investec Asset Management | 19,844,776 | 3.72% |
| Aviva plc & its subsidiaries | 18,255,256 | 3.86% |
| Artemis Investment Management LLP | 16,304,802 | 3.06% |
| John Dawson | 16,200,462 | 3.00% |
| Old Mutual Asset Managers (UK) Ltd | 7,488,920 | 3.15% |