| Trade date | Director | Volume / Price | Trade value | Trade type |
|---|---|---|---|---|
| 21/11/2023 | Hans-Peter Hasler | 2,000,000 @ 6.10p | £122,000.00 | Buy |
| 23/12/2022 | Greg Madison | 466,395 @ 6.80p | £31,714.86 | Sell |
| 19/03/2021 | Christian Schweiger | 0 @ 0.00 | 0.00 | Notification of Holding |
| 17/03/2021 | Peter Llewellyn-Davies | 1,176 @ 30.00p | £352.80 | Placing |
| 17/03/2021 | Christian Schweiger | 250,000 @ 30.00p | £75,000.00 | Placing |
| 05/03/2021 | Hans-Peter Hasler | 200,000 @ 37.50p | £75,000.00 | Buy |
| 03/03/2021 | Hans-Peter Hasler | 200,000 @ 37.38p | £74,760.00 | Buy |
| 20/01/2021 | Hans-Peter Hasler | 100,000 @ 59.00p | £59,000.00 | Buy |
| 19/01/2021 | Tim Watts | 100,000 @ 60.25p | £60,250.00 | Buy |
| 18/12/2020 | Tim Watts | 100,000 @ 1.50p | £1,500.00 | Exercise of Option |
| 11/12/2020 | Tim Watts | 100,000 @ 69.75p | £69,750.00 | Buy |
| 13/08/2019 | James M Karis | 75,000 @ 178.00p | £133,500.00 | Buy |
| 25/04/2019 | Mark Sampson | 22,042 @ 90.70p | £19,992.09 | Buy |
| 25/03/2019 | Mark Sampson | 22,875 @ 87.40p | £19,992.75 | Buy |
| 16/04/2019 | Carl Sterritt | 123,690 @ 1.50p | £1,855.35 | Exercise of Option |
| 16/04/2019 | James M Karis | 4,000 @ 81.00p | £3,240.00 | Buy |
| 15/04/2019 | James M Karis | 46,000 @ 81.50p | £37,490.00 | Buy |
| 21/09/2018 | Carl Sterritt | 88,235 @ 34.00p | £29,999.90 | Buy |
| 04/10/2017 | Carl Sterritt | 8,814 @ 100.00p | £8,814.00 | Exercise of Option |
| Name | Holding | Percent |
|---|---|---|
| Hans-Peter Hasler | 5,500,000 | 0.00% |
| Greg Madison | 533,605 | 0.00% |
| Christian Schweiger | 0 | 0.00% |
| Peter Llewellyn-Davies | 0 | 0.00% |
| Institution name | Holding | Percent |
|---|---|---|
| AOP Orphan Pharmaceuticals AG | 158,070,394 | 26.99% |
| Nutrition-Wellness Venture SA | 56,008,541 | 7.85% |
| Jupiter Fund Management plc | 34,127,697 | 4.78% |
| Premier Miton Group PLC | 30,000,000 | 5.41% |
| MaRu AG | 12,532,918 | 0.00% |
| JPMorgan Asset Management Holdings Inc. | 6,238,846 | 5.37% |
| Universities Superannuation Scheme Ltd | 5,067,985 | 2.35% |