| Trade date | Director | Volume / Price | Trade value | Trade type |
|---|---|---|---|---|
| 13/11/2023 | Michael Hayden | 10,000 @ 192.81p | £19,281.00 | Buy |
| 13/11/2023 | Michael Hayden | 10,000 @ 192.81p | £19,281.00 | Buy |
| 09/10/2023 | Namrata P Patel | 1,670 @ 299.00p | £4,993.30 | Buy |
| 26/09/2023 | Michael Hayden | 12,000 @ 293.50p | £35,220.00 | Buy |
| 26/09/2023 | Dame Kay Davies | 1,000 @ 291.00p | £2,910.00 | Buy |
| 26/09/2023 | Leone Patterson | 6,598 @ 290.50p | £19,167.19 | Buy |
| 20/09/2023 | Stuart Henderson | 1,000 @ 274.97p | £2,749.70 | Buy |
| 20/09/2023 | Catherine Moukheibir | 7,226 @ 274.30p | £19,820.92 | Buy |
| 20/09/2023 | Leone Patterson | 5,849 @ 274.45p | £16,052.58 | Buy |
| 20/09/2023 | Stuart Paynter | 4,030 @ 248.10p | £9,998.43 | Buy |
| 20/09/2023 | Frank Mathias | 20,000 @ 274.98p | £54,996.00 | Buy |
| 20/09/2023 | Roch Doliveux | 36,130 @ 274.30p | £99,104.59 | Buy |
| 03/07/2023 | Catherine Moukheibir | 6,684 @ 430.00p | £28,741.20 | Buy |
| 03/07/2023 | Heather Preston | 6,684 @ 430.00p | £28,741.20 | Buy |
| 03/07/2023 | Michael Hayden | 6,684 @ 430.00p | £28,741.20 | Buy |
| 11/10/2022 | Catherine Moukheibir | 8,910 @ 317.00p | £28,244.70 | Buy |
| 11/10/2022 | Siyamak Rasty | 9,379 @ 317.00p | £29,731.43 | Buy |
| 11/10/2022 | Heather Preston | 9,379 @ 317.00p | £29,731.43 | Buy |
| 11/10/2022 | Michael Hayden | 9,379 @ 317.00p | £29,731.43 | Buy |
| 21/04/2022 | Roch Doliveux | 58,219 @ 589.00p | £342,909.91 | Buy |
| 20/04/2022 | Roch Doliveux | 29,000 @ 536.00p | £155,440.00 | Buy |
| 20/04/2022 | Stuart Paynter | 3,915 @ 508.00p | £19,888.20 | Buy |
| 29/09/2021 | Michael Hayden | 1,910 @ 1,507.50p | £28,793.25 | Buy |
| 23/06/2021 | Siyamak Rasty | 2,235 @ 1,288.00p | £28,786.80 | Buy |
| 23/06/2021 | Heather Preston | 2,235 @ 1,288.00p | £28,786.80 | Buy |
| 30/11/2020 | Andrew Heath | 15,756 @ 869.00p | £136,919.64 | Sell |
| 30/11/2020 | Andrew Heath | 28,597 @ 869.00p | £248,507.93 | Sell |
| 22/10/2020 | Martin Diggle | 25,000 @ 780.00p | £195,000.00 | Buy |
| 01/07/2020 | Martin Diggle | 8,181 @ 720.00p | £58,903.20 | Buy |
| 30/06/2020 | Andrew Heath | 3,000 @ 707.00p | £21,210.00 | Buy |
| 30/06/2020 | Andrew Heath | 1,000 @ 704.00p | £7,040.00 | Sell |
| 30/06/2020 | Andrew Heath | 3,000 @ 705.00p | £21,150.00 | Sell |
| 30/06/2020 | Andrew Heath | 2,000 @ 706.00p | £14,120.00 | Buy |
| 22/06/2020 | Martin Diggle | 134,149 @ 808.00p | £1,083,923.92 | Buy |
| 22/06/2020 | Martin Diggle | 89,434 @ 808.00p | £722,626.72 | Buy |
| 19/06/2020 | John Dawson | 1,875 @ 800.00p | £15,000.00 | Placing |
| 19/06/2020 | Stuart Henderson | 937 @ 800.00p | £7,496.00 | Placing |
| 19/06/2020 | Stuart Paynter | 2,500 @ 800.00p | £20,000.00 | Placing |
| 27/05/2020 | Lorenzo Tallarigo | 365 @ 733.00p | £2,675.45 | Buy |
| 06/05/2020 | Stuart Paynter | 1,472 @ 675.00p | £9,936.00 | Buy |
| 24/04/2020 | Lorenzo Tallarigo | 367 @ 729.00p | £2,675.43 | Buy |
| 25/03/2020 | Lorenzo Tallarigo | 482 @ 555.00p | £2,675.10 | Buy |
| 18/03/2020 | Martin Diggle | 7,378 @ 382.90p | £28,250.36 | Buy |
| 26/02/2020 | Lorenzo Tallarigo | 438 @ 610.00p | £2,671.80 | Buy |
| 31/01/2020 | Lorenzo Tallarigo | 445 @ 601.00p | £2,674.45 | Buy |
| 19/12/2019 | Lorenzo Tallarigo | 415 @ 644.00p | £2,672.60 | Buy |
| 26/11/2019 | Lorenzo Tallarigo | 470 @ 569.00p | £2,674.30 | Buy |
| 25/09/2019 | Lorenzo Tallarigo | 482 @ 554.00p | £2,670.28 | Buy |
| 13/09/2019 | Martin Diggle | 10,000 @ 546.00p | £54,600.00 | Buy |
| 13/09/2019 | Andrew Heath | 3,000 @ 568.00p | £17,040.00 | Buy |
| 13/09/2019 | Andrew Heath | 2,000 @ 556.00p | £11,120.00 | Buy |
| 13/09/2019 | Stuart Henderson | 1,248 @ 557.00p | £6,951.36 | Buy |
| 13/09/2019 | Stuart Paynter | 3,395 @ 586.00p | £19,894.70 | Buy |
| 12/09/2019 | Martin Diggle | 17,953 @ 577.00p | £103,588.81 | Buy |
| 23/08/2019 | Lorenzo Tallarigo | 427 @ 626.00p | £2,673.02 | Buy |
| 25/07/2019 | Lorenzo Tallarigo | 368 @ 730.00p | £2,686.40 | Buy |
| 26/06/2019 | Lorenzo Tallarigo | 370 @ 722.40p | £2,672.88 | Buy |
| 23/05/2019 | Lorenzo Tallarigo | 388 @ 689.50p | £2,675.26 | Buy |
| 25/04/2019 | Lorenzo Tallarigo | 379 @ 706.00p | £2,675.74 | Buy |
| 23/04/2019 | Andrew Heath | 3,312 @ 673.00p | £22,289.76 | Buy |
| 23/04/2019 | Andrew Heath | 2,711 @ 668.00p | £18,109.48 | Buy |
| 25/03/2019 | Lorenzo Tallarigo | 382 @ 695.00p | £2,654.90 | Buy |
| 25/03/2019 | Lorenzo Tallarigo | 382 @ 695.00p | £2,654.90 | Buy |
| 25/02/2019 | Lorenzo Tallarigo | 413 @ 644.00p | £2,659.72 | Buy |
| 06/02/2019 | Andrew Heath | 981 @ 713.00p | £6,994.53 | Sell |
| 06/02/2019 | Andrew Heath | 972 @ 715.00p | £6,949.80 | Buy |
| 06/02/2019 | Andrew Heath | 2,820 @ 704.00p | £19,852.80 | Buy |
| 06/02/2019 | Andrew Heath | 2,832 @ 703.00p | £19,908.96 | Sell |
| 04/02/2019 | Andrew Heath | 2,000 @ 709.00p | £14,180.00 | Buy |
| 04/02/2019 | Andrew Heath | 2,000 @ 689.00p | £13,780.00 | Buy |
| 24/01/2019 | Lorenzo Tallarigo | 383 @ 694.00p | £2,658.02 | Buy |
| 18/01/2019 | Stuart Paynter | 1,622 @ 613.00p | £9,942.86 | Buy |
| 17/01/2019 | Andrew Heath | 2,000 @ 616.00p | £12,320.00 | Buy |
| 17/01/2019 | Andrew Heath | 2,000 @ 616.00p | £12,320.00 | Buy |
| 23/11/2018 | Lorenzo Tallarigo | 406 @ 653.90p | £2,654.83 | Buy |
| 22/10/2018 | Lorenzo Tallarigo | 353 @ 753.76p | £2,660.77 | Buy |
| 24/09/2018 | Lorenzo Tallarigo | 291 @ 912.85p | £2,656.39 | Buy |
| 22/08/2018 | Lorenzo Tallarigo | 302 @ 880.54p | £2,659.23 | Buy |
| 07/08/2018 | John Dawson | 10,046 @ 890.11p | £89,420.45 | Sell |
| 07/08/2018 | John Dawson | 20,000 @ 50.00p | £10,000.00 | Exercise of Option |
| 23/07/2018 | Lorenzo Tallarigo | 306 @ 867.00p | £2,653.02 | Buy |
| 22/06/2018 | Lorenzo Tallarigo | 262 @ 1,019.00p | £2,669.78 | Buy |
| 23/05/2018 | Lorenzo Tallarigo | 17,702 @ 15.00p | £2,655.30 | Buy |
| 23/04/2018 | Lorenzo Tallarigo | 22,055 @ 12.00p | £2,646.60 | Buy |
| 10/04/2018 | Martin Diggle | 1,000,000 @ 11.00p | £110,000.00 | Buy |
| 09/04/2018 | Andrew Heath | 120,720 @ 11.00p | £13,279.20 | Buy |
| 09/04/2018 | Andrew Heath | 72,194 @ 11.00p | £7,941.34 | Buy |
| 09/04/2018 | Stuart Paynter | 87,626 @ 11.20p | £9,814.11 | Buy |
| 05/04/2018 | Peter Nolan | 371,450 @ 10.80p | £40,116.60 | Buy |
| 22/03/2018 | Lorenzo Tallarigo | 22,066 @ 12.00p | £2,647.92 | Buy |
| 23/02/2018 | Lorenzo Tallarigo | 22,121 @ 12.00p | £2,654.52 | Buy |
| 15/01/2018 | Lorenzo Tallarigo | 23,941 @ 11.10p | £2,657.45 | Buy |
| 20/12/2017 | Lorenzo Tallarigo | 29,365 @ 9.00p | £2,642.85 | Buy |
| 23/11/2017 | Lorenzo Tallarigo | 30,861 @ 8.60p | £2,654.05 | Buy |
| 23/10/2017 | Lorenzo Tallarigo | 30,436 @ 8.70p | £2,647.93 | Buy |
| 26/09/2017 | Andrew Heath | 110,511 @ 9.05p | £10,001.25 | Buy |
| 22/09/2017 | Lorenzo Tallarigo | 29,685 @ 8.90p | £2,641.97 | Buy |
| 15/09/2017 | Martin Diggle | 100,000 @ 8.10p | £8,100.00 | Buy |
| 31/08/2017 | Martin Diggle | 2,377,600 @ 10.09p | £239,899.84 | Sell |
| 01/09/2017 | Martin Diggle | 320,000 @ 9.40p | £30,080.00 | Buy |
| Name | Holding | Percent |
|---|---|---|
| Roch Doliveux | 309,808 | 0.00% |
| Michael Hayden | 39,973 | 0.00% |
| Catherine Moukheibir | 25,756 | 0.00% |
| Frank Mathias | 20,000 | 0.00% |
| Stuart Paynter | 18,687 | 0.00% |
| Heather Preston | 18,298 | 0.00% |
| Leone Patterson | 12,447 | 0.00% |
| Stuart Henderson | 10,862 | 0.00% |
| Namrata P Patel | 9,170 | 0.00% |
| Dame Kay Davies | 1,000 | 0.00% |
| Institution name | Holding | Percent |
|---|---|---|
| Novo Nordisk Foundation | 12,048,802 | 11.45% |
| VULPES LIFE SCIENCES FUND | 8,426,390 | 8.43% |
| M&G Plc | 7,170,330 | 7.17% |
| Institut Merieux SA | 6,309,374 | 6.31% |
| Liontrust Asset Management | 6,078,799 | 6.08% |
| Legal & General Group Plc | 5,760,126 | 0.00% |
| Ameriprise Financial, Inc. | 5,371,847 | 5.10% |
| HSBC Global Custody Nominee (UK) Ltd | 4,700,000 | 8.69% |
| BlackRock | 3,743,084 | 3.55% |
| Canaccord Genuity Group Inc | 3,699,438 | 4.82% |
| Hargreaves Lansdown Asset Management | 3,689,888 | 3.69% |
| SERUM LIFE SCIENCES LTD | 3,382,950 | 3.38% |
| Columbia Threadneedle Investments (London) | 3,245,381 | 3.25% |
| Nine Ten Capital | 3,117,228 | 3.80% |
| Lansdowne Partners (London) | 3,085,765 | 3.09% |
| Mr. S Shah | 2,898,750 | 3.50% |
| Artisan Partners | 2,620,800 | 3.20% |
| Cubana Investments Limited | 2,506,000 | 13.26% |
| Interactive Investor Sharedealing | 2,372,412 | 3.10% |
| TDWaterhouse | 852,076 | 4.51% |
| Self Trade Stockbrokers | 657,039 | 3.48% |