| Trade date | Director | Volume / Price | Trade value | Trade type |
|---|---|---|---|---|
| 05/12/2023 | Lindy Durrant | 272,727 @ 11.00p | £29,999.97 | Buy |
| 05/12/2023 | Jean-Michel Cosséry | 454,545 @ 11.00p | £49,999.95 | Buy |
| 02/03/2022 | Martin Diggle | 250,000 @ 12.00p | £30,000.00 | Buy |
| 02/11/2021 | Martin Diggle | 200,000 @ 19.00p | £38,000.00 | Buy |
| 29/10/2021 | Martin Diggle | 100,000 @ 19.00p | £19,000.00 | Buy |
| 09/09/2021 | Lindy Durrant | 2,380,952 @ 21.00p | £499,999.92 | Sell |
| 09/09/2021 | Lindy Durrant | 4,459,681 @ 20.38p | £908,882.99 | Sell |
| 29/07/2021 | Martin Diggle | 200,000 @ 19.50p | £39,000.00 | Buy |
| 04/06/2021 | Martin Diggle | 350,000 @ 19.25p | £67,375.00 | Buy |
| 04/06/2021 | Martin Diggle | 50,000 @ 19.25p | £9,625.00 | Buy |
| 29/04/2021 | Martin Diggle | 400,000 @ 20.40p | £81,600.00 | Buy |
| 18/02/2021 | Martin Diggle | 200,000 @ 27.50p | £55,000.00 | Sell |
| 18/02/2021 | Martin Diggle | 200,000 @ 27.00p | £54,000.00 | Sell |
| 17/02/2021 | Martin Diggle | 250,000 @ 26.50p | £66,250.00 | Sell |
| 17/02/2021 | Martin Diggle | 300,000 @ 26.00p | £78,000.00 | Sell |
| 17/02/2021 | Martin Diggle | 200,000 @ 25.50p | £51,000.00 | Sell |
| 17/02/2021 | Martin Diggle | 200,000 @ 25.00p | £50,000.00 | Sell |
| 17/02/2021 | Martin Diggle | 200,000 @ 24.50p | £49,000.00 | Sell |
| 17/02/2021 | Martin Diggle | 100,000 @ 24.00p | £24,000.00 | Sell |
| 16/02/2021 | Martin Diggle | 400,000 @ 23.70p | £94,800.00 | Sell |
| 14/12/2020 | Martin Diggle | 750,000 @ 10.50p | £78,750.00 | Buy |
| 11/12/2020 | Martin Diggle | 248,823 @ 1,050.00p | £2,612,641.50 | Buy |
| 24/11/2020 | Cliff Holloway | 100,000 @ 11.47p | £11,470.00 | Buy |
| 12/11/2020 | Martin Diggle | 100,000 @ 11.00p | £11,000.00 | Placing |
| 11/11/2020 | Martin Diggle | 100,000 @ 11.40p | £11,400.00 | Placing |
| 10/11/2020 | Martin Diggle | 300,000 @ 12.20p | £36,600.00 | Placing |
| 06/11/2020 | Martin Diggle | 3,670,635 @ 13.00p | £477,182.55 | Placing |
| 12/08/2020 | Sally Adams | 7,705 @ 5.50p | £423.78 | Placing |
| 12/08/2020 | Lindy Durrant | 130,649 @ 5.50p | £7,185.70 | Placing |
| 27/04/2020 | Martin Diggle | 1,500,000 @ 8.00p | £120,000.00 | Sell |
| 24/04/2020 | Martin Diggle | 500,000 @ 8.00p | £40,000.00 | Sell |
| 16/12/2019 | Martin Diggle | 2,925,000 @ 5.20p | £152,100.00 | Buy |
| 24/07/2018 | John Chiplin | 2,483 @ 11.70p | £290.51 | Buy |
| 24/07/2018 | John Chiplin | 2,483 @ 11.00p | £273.13 | Sell |
| 08/05/2018 | Sally Adams | 3,095 @ 12.00p | £371.40 | Placing |
| 08/05/2018 | Katherine Cornish-Bowden | 10,928 @ 12.00p | £1,311.36 | Placing |
| 11/05/2017 | John Chiplin | 1,041,177 @ 10.00p | £104,117.70 | Placing |
| 10/12/2013 | Richard Goodfellow | 0 @ 0.00 | 0.00 | Notification of Holding |
| 10/12/2013 | Lindy Durrant | 0 @ 0.00 | 0.00 | Notification of Holding |
| 21/10/2013 | Lindy Durrant | 100,000 @ 30.00p | £30,000.00 | Sell |
| 21/10/2013 | Richard Goodfellow | 100,000 @ 30.00p | £30,000.00 | Sell |
| 22/07/2013 | Peter Allen | 50,000 @ 33.00p | £16,500.00 | Buy |
| 22/07/2013 | Katherine Cornish-Bowden | 45,000 @ 32.00p | £14,400.00 | Buy |
| 22/07/2013 | David Evans | 30,000 @ 31.80p | £9,540.00 | Buy |
| 30/07/2010 | David Evans | 510,000 @ 0.00 | 0.00 | Notification of Holding |
| 30/07/2010 | Richard Goodfellow | 664,384 @ 0.00 | 0.00 | Notification of Holding |
| 30/07/2010 | Lindy Durrant | 1,483,973 @ 0.00 | 0.00 | Notification of Holding |
| Name | Holding | Percent |
|---|---|---|
| Martin Diggle | 117,729,029 | 14.00% |
| Jean-Michel Cosséry | 454,545 | 0.00% |
| Lindy Durrant | 272,727 | 0.00% |
| Sally Adams | 69,623 | 0.00% |
| Institution name | Holding | Percent |
|---|---|---|
| Redmile Group, LLC | 268,616,936 | 28.95% |
| VULPES LIFE SCIENCES FUND | 117,729,029 | 14.44% |
| Ferlim Nominees Limited | 50,632,079 | 13.06% |
| Reyker Nominees Ltd | 48,464,691 | 18.53% |
| Hargreaves Lansdown | 33,619,839 | 8.67% |
| Share Nominees Ltd. | 29,887,768 | 7.71% |
| The Bank of New York Nominees Limited | 21,287,775 | 5.49% |
| Legal & General Group Plc | 18,167,000 | 4.72% |
| Nortrust Nominees Limited | 18,167,000 | 4.68% |
| City Financial Investment Company Limited | 16,287,775 | 4.20% |
| Barclayshare Nominees Ltd | 15,650,629 | 5.98% |
| Lynchwood Nominees Ltd. | 15,085,721 | 5.77% |
| Rock Nominees Limited | 13,445,702 | 3.47% |
| Hygea VCT | 13,149,730 | 3.50% |
| Huntress Nominees (CI) Limited | 11,309,220 | 4.32% |
| Layton Trustees & L.G. Durrant | 8,773,960 | 3.97% |
| JG Helfenstein | 7,000,000 | 3.13% |