| Trade date | Director | Volume / Price | Trade value | Trade type |
|---|---|---|---|---|
| 25/06/2024 | Robert Hutchinson | 26,573 @ 111.60p | £29,655.47 | Buy |
| 09/03/2022 | Robert Hutchinson | 26,000 @ 171.80p | £44,668.00 | Buy |
| 11/05/2021 | Thomas Henderson | 2,137,172 @ 202.05p | £4,318,156.03 | Sell |
| 10/05/2021 | Thomas Henderson | 639,885 @ 222.12p | £1,421,312.56 | Sell |
| 10/05/2021 | Thomas Henderson | 3,222,943 @ 223.88p | £7,215,524.79 | Sell |
| 01/04/2021 | Thomas Henderson | 317,961 @ 250.01p | £794,934.30 | Sell |
| 26/03/2021 | Kemal Malik | 11,475 @ 261.75p | £30,035.81 | Buy |
| 26/03/2021 | Gian Piero Reverberi | 10,000 @ 261.00p | £26,100.00 | Buy |
| 26/03/2021 | Virginia Holmes | 38,000 @ 260.50p | £98,990.00 | Buy |
| 15/06/2020 | Gian Piero Reverberi | 17,399 @ 222.50p | £38,712.78 | Buy |
| 15/06/2020 | Gian Piero Reverberi | 1,900 @ 222.00p | £4,218.00 | Buy |
| 15/06/2020 | Gian Piero Reverberi | 4,701 @ 221.50p | £10,412.72 | Buy |
| 26/03/2020 | Melanie Gee | 26,500 @ 186.60p | £49,449.00 | Buy |
| 27/03/2020 | Melanie Gee | 10,405 @ 190.70p | £19,842.34 | Buy |
| 27/03/2020 | Melanie Gee | 10,405 @ 190.40p | £19,811.12 | Sell |
| 18/03/2020 | Robert Hutchinson | 25,480 @ 194.80p | £49,635.04 | Buy |
| 03/03/2020 | Thomas Henderson | 1,000,000 @ 247.00p | £2,470,000.00 | Sell |
| 22/03/2019 | Nick Moss | 8,004 @ 249.70p | £19,985.99 | Buy |
| 18/03/2019 | Ellen Strahlman | 45,185 @ 244.19p | £110,337.25 | Buy |
| 14/03/2019 | Gian Piero Reverberi | 16,000 @ 253.40p | £40,544.00 | Buy |
| 14/03/2019 | Robert Hutchinson | 19,775 @ 251.00p | £49,635.25 | Buy |
| 30/07/2018 | Ellen Strahlman | 1,054 @ 241.80p | £2,548.57 | Dividend Reinvestment |
| 30/07/2018 | Jeremy Tigue | 4,504 @ 241.80p | £10,890.67 | Dividend Reinvestment |
| 17/01/2018 | Robert Hutchinson | 23,140 @ 214.50p | £49,635.30 | Buy |
| 11/10/2017 | Thomas Henderson | 3,000,000 @ 185.00p | £5,550,000.00 | Sell |
| 23/08/2017 | Peter Hames | 1,250 @ 171.84p | £2,148.00 | Dividend Reinvestment |
| 23/08/2017 | Jeremy Tigue | 6,254 @ 171.84p | £10,746.87 | Dividend Reinvestment |
| 07/08/2017 | Ellen Strahlman | 290 @ 173.50p | £503.15 | Buy |
| 07/08/2017 | Ellen Strahlman | 22,810 @ 172.60p | £39,370.06 | Buy |
| 04/08/2017 | Ellen Strahlman | 5,348 @ 173.00p | £9,252.04 | Buy |
| 02/08/2017 | Ellen Strahlman | 634 @ 172.00p | £1,090.48 | Buy |
| 01/08/2017 | Ellen Strahlman | 9,359 @ 171.60p | £16,060.04 | Buy |
| 28/07/2017 | Ellen Strahlman | 122 @ 171.90p | £209.72 | Buy |
| 28/07/2017 | Ellen Strahlman | 634 @ 172.00p | £1,090.48 | Buy |
| 28/07/2017 | Ellen Strahlman | 20,016 @ 171.90p | £34,407.50 | Buy |
| 27/07/2017 | Ellen Strahlman | 637 @ 174.00p | £1,108.38 | Buy |
| 28/07/2017 | Ellen Strahlman | 110 @ 171.90p | £189.09 | Buy |
| 28/07/2017 | Ellen Strahlman | 2,230 @ 172.00p | £3,835.60 | Buy |
| 27/07/2017 | Ellen Strahlman | 21,558 @ 172.40p | £37,165.99 | Buy |
| 27/07/2017 | Ellen Strahlman | 1,409 @ 174.00p | £2,451.66 | Buy |
| 19/12/2016 | Nick Moss | 4,822 @ 131.15p | £6,324.05 | Buy |
| 19/12/2016 | Thomas Henderson | 300,000 @ 131.15p | £393,450.00 | Buy |
| 19/12/2016 | Peter Hames | 22,430 @ 131.15p | £29,416.95 | Buy |
| 19/12/2016 | Jeremy Tigue | 112,154 @ 131.15p | £147,089.97 | Buy |
| 19/08/2016 | Nick Moss | 270 @ 0.00 | 0.00 | Buy |
| 19/08/2016 | Peter Hames | 1,256 @ 0.00 | 0.00 | Scrip Dividend |
| 19/08/2016 | Jeremy Tigue | 6,282 @ 0.00 | 0.00 | Scrip Dividend |
| 19/08/2016 | Arabella Cecil | 6,973 @ 0.00 | 0.00 | Scrip Dividend |
| 21/03/2016 | Nick Moss | 15,000 @ 130.50p | £19,575.00 | Buy |
| 09/12/2015 | Martin Thomas | 77,664 @ 128.74p | £99,984.63 | Buy |
| 19/08/2015 | Martin Thomas | 3,230 @ 0.00 | 0.00 | Scrip Dividend |
| 19/08/2015 | Peter Hames | 1,166 @ 0.00 | 0.00 | Scrip Dividend |
| 19/08/2015 | Colin Maltby | 1,166 @ 0.00 | 0.00 | Scrip Dividend |
| 19/08/2015 | Jonathan Paul Moulton | 17,299 @ 0.00 | 0.00 | Scrip Dividend |
| 19/08/2015 | Jeremy Tigue | 5,832 @ 0.00 | 0.00 | Scrip Dividend |
| 15/07/2015 | Martin Thomas | 38,229 @ 130.79p | £49,999.71 | Buy |
| 07/07/2015 | Thomas Henderson | 5,000,000 @ 128.50p | £6,425,000.00 | Sell |
| 31/03/2015 | Thomas Henderson | 0 @ 0.00 | 0.00 | Notification of Holding |
| 02/04/2015 | Martin Thomas | 12,268 @ 122.15p | £14,985.36 | Buy |
| 10/09/2014 | Peter Hames | 1,183 @ 113.90p | £1,347.44 | Buy |
| 10/09/2014 | Martin Thomas | 2,407 @ 113.90p | £2,741.57 | Buy |
| 10/09/2014 | Jonathan Paul Moulton | 17,559 @ 113.90p | £19,999.70 | Buy |
| 10/09/2014 | Colin Maltby | 1,183 @ 113.90p | £1,347.44 | Buy |
| 10/09/2014 | Jeremy Tigue | 5,919 @ 113.90p | £6,741.74 | Buy |
| 31/03/2013 | Martin Thomas | 0 @ 0.00 | 0.00 | Notification of Holding |
| 31/03/2013 | Jonathan Paul Moulton | 0 @ 0.00 | 0.00 | Notification of Holding |
| 31/03/2013 | Colin Maltby | 0 @ 0.00 | 0.00 | Notification of Holding |
| 31/03/2013 | Thomas Henderson | 0 @ 0.00 | 0.00 | Notification of Holding |
| 31/03/2013 | Peter Hames | 0 @ 0.00 | 0.00 | Notification of Holding |
| 31/03/2013 | Jeremy Tigue | 0 @ 0.00 | 0.00 | Notification of Holding |
| Name | Holding | Percent |
|---|---|---|
| Robert Hutchinson | 121,400 | 0.00% |
| Melanie Gee | 76,500 | 0.00% |
| Gian Piero Reverberi | 50,000 | 0.00% |
| Virginia Holmes | 38,000 | 0.00% |
| Kemal Malik | 11,475 | 0.00% |
| Institution name | Holding | Percent |
|---|---|---|
| North London Ventures Limited | 243,461,685 | 36.98% |
| The Wellcome Trust | 186,000,000 | 27.79% |
| BlackRock, Inc. | 69,185,088 | 10.32% |
| Schroders plc | 33,488,292 | 5.00% |
| Smith and Williamson Holdings Limited | 32,849,272 | 4.98% |
| Waverton Investment Management Limited | 31,640,760 | 4.75% |
| Sarasin & Partners LLP | 30,934,159 | 4.62% |
| Legal & General Group Plc (Group) | 26,834,153 | 4.05% |
| J O Hambro Investment Management Limited | 23,218,940 | 6.09% |
| RATHBONE BROTHERS PLC | 22,583,470 | 3.43% |
| Cazenove Capital Management Limited | 20,177,500 | 9.76% |
| Bestinvest (Brokers) Limited | 19,649,263 | 9.82% |
| J.M. FINN & CO LTD | 19,181,655 | 4.97% |
| Royal Bank of Canada | 10,621,570 | 2.76% |