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30 May 2024

Genflow Biosciences Plc 

Receipt of Grant Funding

Genflow Biosciences Plc (LSE:GENF)(OTCQB:GENFF) ("Genflow" or "the Company") an emerging leader in the field of longevity research, focused on developing therapeutic solutions for the prevention of age-related diseases is pleased to announce receipt of 50% of its substantial non-diluting and non-reimbursable research grant. The amount received totals €381,434 from the Government of Wallonia in Belgium's Advanced Therapy Medicinal Products (ATMPs).

Genflow, together with its partner Revatis SA, has launched a 3-year sarcopenia research program [see news release here]. The remaining funds from the grant will be disbursed over the next two years based on submitted invoices. The grant will be utilized as working capital to support the Sarcopenia project.  

The Sarcopenia Project focuses on the development of muscle progenitor cells (MPCs) which will be loaded with Genflow's proprietary SIRT6 for the prevention and treatment of sarcopenia. This innovative approach aims to address the underlying causes of sarcopenia and promote muscle regeneration. Muscle progenitor cells are a type of stem cell capable of differentiating into muscle cells, playing a crucial role in muscle repair and regeneration. In sarcopenic muscles, the activity and number of MPCs decline, leading to impaired muscle regeneration. By loading MPCs with the SIRT6 gene, Genflow aims to enhance the regenerative capacity of these cells and counteract the detrimental effects of aging on muscle tissue.

Dr. Eric Leire, CEO of Genflow commented: "Sarcopenia, the age-related loss of muscle mass and function, is a significant health issue affecting older adults worldwide. Genflow aims to counteract the detrimental effects of aging on muscle tissue with our Sarcopenia program, which holds potential for significantly improving the quality of life for older adults affected by muscle loss and weakness."

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About Genflow Biosciences

Founded in 2020, Genflow Biosciences Plc. (LSE:GENF) (OTCQB:GENFF), a biotechnology company headquartered in the UK with R&D facilities in Belgium, is pioneering gene therapies to decelerate the aging process, with the goal of promoting longer and healthier lives while mitigating the financial, emotional, and social impacts of a fast-growing aging global population. Genflow's lead compound, GF-1002, works through the delivery of a centenarian variant of the SIRT6 gene which has yielded promising preclinical results. Scheduled to begin in 2025, Genflow's clinical trial aims to explore the potential benefits of GF-1002 in treating MASH (Metabolic Dysfunction-Associated Steatohepatitis), the most prevalent chronic liver disease for which there is no effective treatments. Please visit www.genflowbio.com  and follow the Company on LinkedIn and Twitter/X.

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