Provexis PLC 23 January 2006 PROVEXIS PLC ("Provexis" or the "Company") Significant Increase in Number of Distribution Outlets for SircoTM Provexis, the nutraceutical company that develops scientifically-proven functional and medical foods, announces a significant increase in the number of distribution outlets for its SircoTM heart health juice drink, under the terms of its most recent distribution agreement with a market leading supermarket chain. Further to the Company's announcement of 9 January 2006 detailing its third distribution agreement, SircoTM will now be available in 550 of this retailer's stores from 30 January 2006, representing an increase of 350 outlets. Sirco is now available in 211 Sainsbury's stores and will be available in 123 Waitrose stores from 23 January 2006. This will bring the total UK distribution base for Sirco to 884 stores by the end of January 2006. SircoTM is the first heart health product to contain the patented FruitflowTM technology. FruitflowTM was developed by Provexis in order to help regular "healthy" consumers reduce the risk of heart attack and stroke. The natural bioactive works by reducing blood platelet aggregation ("thinning the blood"), a significant contributing factor to a thrombosis (internal blood clot). SircoTM carries the health claim "Helps to Maintain a Healthy Heart and Benefits Circulation" and is approved by the leading heart health charity, HEART UK. Commenting on the expanded distribution, Dr Stephen Franklin, CEO of Provexis, said: "We are delighted to have received this substantial increased commitment from the third major retailer prior to the date of its planned launch. Our focused media campaign to consumers is scheduled to commence on 21 January 2006 and our sales support activities have been in effect since 10 January". For further information please contact: Provexis plc Dr Stephen Franklin 020 8392 6631 Bell Pottinger Corporate & Financial Ann-Marie Wilkinson/Emma Kent 020 7861 3232 This information is provided by RNS The company news service from the London Stock Exchange